The aim of the present study was to formulate a clindamycin phosphate and nicotinamide combination gel using allantoin base. Acne vulgaris is a common skin condition with substantial cutaneous and psychologic disease burden. Clindamycin Phosphate and Nicotinamide are approved anti-acne drugs with a potent anti-inflammatory effect. In this study, safety and efficacy of topical 1% clindamycin phosphate and 4% nicotinamide gel in mild and moderate acne vulgaris was investigated. Carbopol-940 was selected as gelling agent with allantoin in the formulated gel. Propylene Glycol was selected as solvent. Evaluate formulation with different parameters i.e. appearence, pH, viscosity, spreadibility, extrudability. Formulation of Clindamycin Phosphate and Nicotinamide gel had the desired properties with respect to their colour, odour, pH, viscosity, drug content, spreadibility, extrudability.
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